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A análise histológica do câncer de mama é fundamental, servindo tanto para estabelecer o diagnóstico quanto para avaliar fatores prognósticos e preditivos. Essa análise é realizada por um médico especialista na área, o Patologista.
Há muitas diferenças entre os tumores de mama, isto é, não existe apenas um tipo de câncer de mama. Existem vários subtipos histológicos, sendo os tipos ductal e o lobular os mais freqüentes (com cerca de 40-75% e 5-15% dos casos, respectivamente – dados da Organização Mundial da Saúde2). Porém, mesmo dentro de um mesmo subtipo, as características diferem de um tumor para outro. As características prognósticas foram, com o trabalho de Ellis e colaboradores em 1991 3, padronizadas sob uma mesma classificação: o índice de Nottingham. Este leva em conta características como a quantidade de formação tubular (se o tumor tende a formar glândulas, como o tecido mamário normal, ou se não se diferencia, formando blocos celulares sólidos), a atipia do núcleo (o quanto ele parece diferente de uma célula normal) e o número de mitoses (mostra o quanto as células tumorais se replicam). A interpretação conjunta destes dados permite a classificação de um tumor em diferentes graus de diferenciação: bem (grau 1), intermediário (grau 2) ou pouco diferenciado (grau 3).
No ano 2000, foi publicado o trabalho de Perou e colaboradores 1 demonstrando que, na verdade, existem ainda mais diferenças entre os tumores de mama. Isto é, mesmo dentro dos tipos histológicos mais comuns, e dos carcinomas com um mesmo grau de diferenciação (grau histológico), há tumores com enormes diferenças comportamentais, isto é, desde tumores mais indolentes até os com rápido crescimento e progressão. Como exemplos nestes subgrupos, podemos citar os subtipos Luminais, HER2 e Triplo Negativos.
Desde então, uma enorme quantidade de recursos vêm sendo investidos no melhor conhecimento dos diferentes tumores. A cada descoberta, as ferramentas disponíveis para avaliação de fatores preditivos e prognósticos aumentam e tornam-se rotina na avaliação dos carcinomas da mama. As características prognósticas clássicas 3, como grau histológico, acometimento linfonodal e margens cirúrgicas, foram associadas a outras, mais recentes, tanto preditivas quanto prognósticas 4, 5, 6, como avaliação de receptores hormonais – possibilitando tratamento hormonioterápicos – ou de superexpressão de HER2 – também com medicamentos específicos – e até mesmo uma melhor avaliação do índice de proliferação tumoral – possibilitando predizer uma possível resposta efetiva aos diferentes medicamentos.
O conjunto destes dados, sob uma análise criteriosa e seqüencial, nos permite agrupar os carcinomas em subgrupos distintos, com diferentes prognósticos e respostas aos tratamentos4.
IMPORTÂNCIA DA ANÁLISE DA MAMA APARENTEMENTE NORMAL
É intuitiva a idéia de que a melhor maneira de resolver um problema é impedir que ele aconteça. No câncer de mama, isso não é diferente. Por isso, as lesões precursoras, isto é, aquelas que antecedem o câncer de mama, assim como as alterações que conferem um maior risco de desenvolvimento do câncer, têm sido extensamente estudadas.
Ferramentas importantes na detecção destas alterações, como um bom exame clínico e radiológico, já estão bem estabelecidas, assim como a sua peridiocidade necessária. No entanto, há lesões iniciais – engoblando tanto lesões precursoras ou ainda aquelas que conferem maior risco para o desenvolvimento do câncer - que escapam da detecção por estes métodos, pois ainda não estão suficientemente desenvolvidas para dar sinais ou sintomas. Apesar de, felizmente, esta situação não ser tão comum, qualquer oportunidade de uma boa avaliação de um tecido aparentemente normal não deve e não pode ser desperdiçada, pois será a única chance de avaliá-lo.
1. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lonning PE, Borresen-Dale AL, Brown PO, Botstein D: Molecular portraits of human breast tumours, Nature 2000, 406:747-752
2. Tavassoli FA, Devilee P: Pathology and Genetics of Tumors of the Breast and Female Genital Organs, 2003,
3. Elston CW, Ellis IO: Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up, Histopathology 1991, 19:403-410
4. Bhargava R, Striebel J, Beriwal S, Flickinger JC, Onisko A, Ahrendt G, Dabbs DJ: Prevalence, morphologic features and proliferation indices of breast carcinoma molecular classes using immunohistochemical surrogate markers, Int J Clin Exp Pathol 2009, 2:444-455
5. Cheang MC, Chia SK, Voduc D, Gao D, Leung S, Snider J, Watson M, Davies S, Bernard PS, Parker JS, Perou CM, Ellis MJ, Nielsen TO: Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer, J Natl Cancer Inst 2009, 101:736-750
6. Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, Hernandez-Boussard T, Livasy C, Cowan D, Dressler L, Akslen LA, Ragaz J, Gown AM, Gilks CB, van de Rijn M, Perou CM: Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma, Clin Cancer Res 2004, 10:5367-5374
Texto escrito por Dr. Fernando Nalesso Aguiar (CRM-SP 120.274) – Médico Patologista do Instituto do Câncer do Estado de São Paulo “Octavio Frias de Oliveira” – ICESP PS3 EMULATORRevised on 13 de março de 2012
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At the moment, there are 1.3 billion Whatsapp users. This is a significant increase if you know that in 2016, the number was 1 billion.
Obviously, due to simplicity and functionality, we can only assume that the number of users will go in one direction only, up!
But, this also means that a higher number of people will want to hack Whatsapp account.
Yes, this is possible and there are 4 methods you can use.
Part 1. Hack whatsapp chat history:
Hack Someone's WhatsApp Messages without them Knowing Using Copy9
Copy9 is the first method on our list. Basically, it is a full-size app which allows you to get a complete access to a targeted device.
In recent months, we have been able to see a huge increase in the number of users. They are parents and business owners, among others.
The main idea behind the app in question was to provide safety and security, rather than to use it for plain smartphone hacking, which is something we prefer.
Yes, you can still hack Whatsapp messages and read them whenever you want.
Perhaps all of this spends complicated, but the real procedure is more than just simple. In essence, you will have to:
- Step 1: Download The Copy9 App
- Step 2: Install it on targeted device
- Step 3: Login to your control panel on a PC. Done
As you can see, the entire process takes no more than 5 minutes of your time.
It is specifically developed to be simple enough for average users and those who don’t even fully understand smartphones and how they work.
The bottom line is yes, you will be able to use it without a problem.
Here it should be mentioned that there is no risk of being detected!
The app works by connecting to the operating system and literally becoming part of it.
As such, the app has all the access to the OS on your phone, obviously.
The app cannot be detected by antivirus, malware software or on any other way.
Hard reset of a device won’t delete the app as well. At the end, we can add Copy9 is the safest app to use.
The hack Whatsapp online feature
Besides the hack Whatsapp online feature, Copy9 offers plenty of additional features!
The full list of features is significantly long. In general, you will be able to hack Whatsapp chat history, monitor call, all messages, internet activity, GPS, detecting when a SIM card is changed and many other features.
Customer support is guaranteed and also more than just decent, which isn’t a case with apps of this kind!
The best part, you get a free trial, without a need to enter your credit card. If you don’t like it, after 48 hours simply delete the app and you are done.
However, most users who tried the free trial, have been using Copy9 ever since.
Part 2: How to Hack a WhatsApp Account
You will probably want to obtain Whatsapp messages from a targeted device at some point. Although there are so many, different methods, not all of them are simple or effective. But, there is one which stands out from the crowd.
This method involves using the Whatsapp backup extractor. Hacking Whatsapp account is simple and fast, so anyone can use it. In addition, it works for iOS and for Android smartphones.
Hack whatsapp account on Iphone Using Whatsapp backup extractor for iOS devices
This is the most common application of the software in question. All you will have to do is to follow simple steps below. Keep in mind that you will need between 5 and 15 minutes to obtain the Whatsapp messages.
- Step 1: Download and install dr.fone - Recover (iOS)
- Step 2: Click on Repair button and select Whatsapp
- Step 3: Click start scan and wait until it is done
- Step 4
: Once again select files you want to recover
- Step 5: Click on Recover to Computer
Once these files are on your computer, you will have a complete insight into the messages, media files and literally anything which was present in the backup file.
iTunes and iCloud backup extraction
The software in question also works with iTunes and iCloud backups. With this method, you can hack Whatsapp messages without access to phone. Basically, the process is identical as we have mentioned earlier.
- Step 1: Run dr.fone toolkit and click on repair
- Step 2: Choose Recover from iTunes backup file and choose the latest backup
- Step 3: Select Start scan
- Step 4: Select files you want
- Step 5: Recover them to your computer
After the procedure, all the files will be restored to your computer, including messages, media files and etc.
In addition, this method is exactly the same as the first one here, but it uses backup file from iTunes rather than from the targeted device.
When it comes to iCloud extraction, the process is the same. But, you will have to log in to the iCloud account, select the suitable file and then follow the same steps as earlier.
Hack Someone's WhatsApp on Android without them Knowing by Using Whatsapp backup extractor
In this case scenario, you will have to use the dr.fone - Recover (Android) software. Luckily, the method is almost the same.
- Step 1: Connect the device to a computer
- Step 2: Run the dr.fone - Recover (Android)
- Step 3: Select Whatsapp messages and attachment files
- Step 4: Click start scan (scan for all files is recommended)
- Step 5: Recover files you want
There are two additional points we will have to mention here:
Part 3: Hack whatsapp by sending image
How actually safe Whatsapp and similar apps are
You may believe that they are bulletproof, but they aren’t! As a matter of fact, both, Whatsapp and Telegram were able to be hacked by a single photo, yes, just one ordinary photo.
Both of these companies issue a new patch recently which should prevent this issue.
According to the latest details, hackers were able to hack these accounts by sending a photo to a user.
Of course, a photo had to be opened, after which hack would be performed.
The severity of this issue means that your account can be hacked within a matter of seconds.
If you are looking for a way how to hack someone’s Whatsapp without their phone this is the method for you.
So, how this method actually works
Video Demonstration: The researchers also provided a video demonstration, given below which shows the attack in action.
In order to complete it, you will have to insert a malicious code into a photo.
Once a user opens that photo, the code will infect the device, allowing you a complete access.
Within a matter of seconds, you can have a complete control over Whatsapp or Telegram, depending on which app you targeted.
The explanation lies in the process how both of these apps treat media files.
The same applies to videos and documents, by the way. In essence, Whatsapp doesn’t check the files for malware.
It directly allows to the users to open, view and store a photo or a video.
In other words, the app will literally allow access of malware into a device. After which the account is hacked.
A bit more detailed explanation is required here. Telegram, Whatsapp, and a few other apps use the same type of encryption.
It means that an app won’t be aware of the message or a file which is sent to a device until it validates it.
However, the opening is the first step here and only then a message is validated. In plain words, Whatsapp doesn’t realize what has been actually received until it is too late.
Still, want to know how to hack a Whatsapp account using this method
Well, it may be still working among users who haven’t upgraded their Whatsapp.
This method does require knowledge of coding and it is one of the most complicated out there, simply due to the fact you will have to adapt the code according to several parameters.
On the other hand, the main advantage is in the further hacking capabilities.
In essence, once a hacked user sends the same photo to another, he will be hacked as well.
This creates an impressive chain of hacked users, which can be more than just long.
Part 4: Hack whatsapp messages without access to phone
WhatsApp Tracker allows Hackers to Intercept and Read Your Encrypted Messages
This method is perhaps the most appealing of them all. In essence, it uses a “backdoor” flaw.
Some say it is a severe mistake, while others claim it is an additional feature.
Anyway, it allows to you to hack Whatsapp and to read, by intercepting the messages between users. Backdoor is used by Whatsapp, Telegram, and a few more apps.
First of all, we should explain the end-to-end encryption. It means that you, as a user will send an encrypted message to another person.
Only after it is received, it will be decrypted and readable. Whatsapp introduced this feature in 2012 and then became the most secure app of them all. Sadly, it looks like it isn’t so secure.
Whatsapp is owned by Facebook, and if we know that this giant allows to the central intelligence agencies to spy on their users, we can deduce that Whatsapp shares the same flaw.
That’s why the backdoor feature exists. Originally, it has been developed for central intelligence agencies, but at the same time, it is something that hackers can use.
Furthermore, Whatsapp end-to-end encryption works on “trust”. The company uses a secure server to process the messages, but according to the user agreement, they can change any of the rules at any given moment.
Basically, Whatsapp can choose to share your messages with others and you won’t know about it!
The vulnerability relies on the way WhatsApp behaves when an end user’s encryption key changes.
Basically, we have a scenario between users A and a person B.
When a person A sends a few messages to the person B, the Whatsapp on that device will decrypt the messages and allow for the user to read them.
But, when a user B replaces the device, he will also be able to get and read those messages.
This is possible due to the fact Whatsapp choose to update and modify the private keys, needed for decryption at any given moment, without informing the user.
Now, you as a hacker will be user C. You will modify the private key of a user B and insert your own.
By doing so, you will directly be able to read messages of user A. Whatsapp spy app that can do it for you isn’t so complicated to use, after all.
Here we have another advantage of this method. Facebook, which owns Whatsapp didn’t solve this issue since 2016. It is obvious that it will stay available in the future as well.
All of this means that you, as a hacker will be able to exploit this method in the near future. Using Whatsapp tracker online and using this method will give impressive results.
Some believe that backdoor feature is used as a feature to eliminate the need for constant privacy key verification, which is annoying. Instead, Whatsapp will do it instead of you.
But, Signal private messenger, which uses the same technology is immune to this issue, simply due to the fact it requires physical verification.
If you are a decent hacker, you will be able to exploit this method or better said this drawback of the Whatsapp.
After all, it is introduced to allow for agencies to spy on users, which means that hackers, including yourself, can use it for the same reason.
The best way to hack Whatsapp account is:
Obviously, it is Copy9 app
The second method is a bit more demanding. You will need to know the essence of coding.
But, this isn’t something you can learn at school or at some other place.
You will have to be born for this and you will need to understand the matter without the help of anyone else.
Also, once users upgrade the app, you won’t be able to use this method anymore.
The third, backdoor method is still possible and it will stay possible ever since, due to the fact Facebook refuses to change the privacy terms!
In other words, you will be able to use it as long as you want. But, this method is also complicated and probably even more demanding than the second one here.
So, if you choose to use it, take your time, learn the matter and only then try it. By the way, this method can be detected easily by users!
At the end, we should repeat that the best and the easiest way is to use Copy9. It doesn’t require any of the requirements other two methods do, but it offers even better result OO Defrag Professional 16.0.141
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Cara Non Software ini sebenarnya agak rumit Elu yang mau Hack Akun korban minimal harus tau emailnya saja kamu juga harus memiliki email yang domainnya sama, liat kalo domain dia menggunakan @yahoo.com klik aja link ini Yahoo! . Kalo dia menggunakan @gmail.com klik aja disini Gmail.A. Kalau Domainnya @yahoo.com 1. Klik yang sudah ku tanda merahin. 2. Lalu klik "Kata Sandi Saya Bermasalah" lalu klik "Berikutnya". 3. Masukan Email korban. 4. Masukin Kode yang Tertera pada gambar tersebut. 5. Lalu Klik Kirim setelah itu, Klik Opsi Pemulihan yang lain, lalu pada kotak isian Email Alternatif masukin email kamu. 6. Setelah itu buka Yahoo kamu sesuai email yang kamu masukin tadi, lalu cek emailnya masuk lalu klik link nya lalu ganti password deh
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B. Kalau Domainnya @gmail.com 1. Klik yang sudah saya lingkri. 2. Lalu Pilih yang pertama " I don't know my password" Lalu klik continue. 3. Lalu Klik " I Don't know". 4. Lalu klik " I cann't access my phone " 5. Lalu klik yang saya sudah lingkari ( Verify your identity ) 6. Baru masukin Email kamu jgn email korban kamu y! 7. Lalu isi saja terus (asal-asal juga boleh) kalau ada bacaan "Skip these Question". ( Lanjutkan Pertanyaan) klik aja itu. 8. Jika pertanyaan sudah selesai. Buka Gmail kamu sendiri sesuai dengan email yang tadi kamu masukin. 9. Lalu cek di Primary ada email masuk dari GOOGLE, lalu buka, lalu klik link yang telah dikasih oleh pihak google tersebut.
10. Setelah kamu sudah mengetahui Gmail nya lalu klik link berikut https://www.facebook.com/recover.php .11. lalu masukin email korban yang tadi. Lalu Pilih "email me a link to reset my password" lalu klik continue.
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Dengan Menggunakan Software untuk mengetahui email password orang tuh lebih gampang tetapi semua barang tidak ada lah gratis, karena menciptakan sesuatu itu bukanlah gampang melainkan susah. apa salah jika anda membeli FULL Version. Kalo sob kgk percaya cari aja sendiri di google Keynya ane care sampe pusing seratus keliling pun kgk dapet ok lah langsung saya bahasa saja y.A. Facebook Hacker
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You can hack facebook account successfully! Find Password.
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PayPal Hack relies on intelligent algorithms that can access the website server. It generates encrypted codes that turn through the website into the value of money in your account. It’s generating money online that isn’t being used before in a legitimate way. PayPal Money Adder 2017 is 100% safe. It doesn’t ask for a password to log in or any other information.
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8 Ball Pool Long Line Ban protection Guidelines Hack 2017
8 Ball pool Long Line Ban Protection was released, updated and tested on on 30 Jan 2018 ! (Gameroom support added)
Trainer Contains :
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Read the instructions document provided inside the rar file for step by step process of setting up charles Or You can watch the follow video tutorial which contains everything.
Join Our Facebook Group/Page to stay updated and contact the admins any time you like – Facebook Group and Facebook Page
Video Tutorial (Contains the process of Setting up charles Ban protection and Long Line ):
Note: Use the long line and Guideline hack along with ban protection. I have been playing using this hack since a few days now. I have not been banned yet. I haven’t tested this hack in larger tables / in tournaments. If something is not working please let me know by commenting below so that i can fix it asap.
Points to keep in mind before using the long line / Guideline hack :
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